Table 1.

Cross-reactive epitopes in the S2 of SARS-CoV-2 and other coronaviruses.

S2 amino acid residues1	S2 region or domain2	Virus strain	Mode of induction	Study
S785−840	FP	SARS-CoV-2	Natural infection	[46]
S809−826	FP	SARS-CoV-2	Natural infection	[80]
S809−834	FP	SARS-CoV-2	Natural infection	[81]
S810−816	FP	SARS-CoV-2	Natural infection	[32]
S811−830	FP	SARS-CoV-2	Natural infection	[31]
S813−868	FP	SARS-CoV-2	Natural infection	[46]
S817−824	FP	SARS-CoV-2	Natural infection	[32]
S819−824	FP	SARS-CoV-2	Natural infection	[47]
S851−856	FP	SARS-CoV-2	Natural infection	[32]
S910−1213	HR1 to HR2	SARS-CoV-2	Immunisation	[82]
S980−1006	HR1 to CH	MERS-CoV	Immunisation	[90]
S997−1002	CH	SARS-CoV-2	Natural infection	[32]
S1040−1044	CH	SARS-CoV-2	Natural infection	[32]
S1041−1207	CD-SH-HR2	SARS-CoV	Natural infection	[86]
S1073−1210	CD-SH-HR2	SARS-CoV	Immunisation	[83]
S1109−1148	CD-SH	SARS-CoV	Immunisation	[84]
S1121−1176	CD-SH-HR2	SARS-CoV-2	Natural infection	[46]
S1140−1168	SH-HR2	SARS-CoV-2	Natural infection	[81]
S1144−1163	SH	SARS-CoV-2	Natural infection	[31]
S1147−1161	SH	SARS-CoV-2	Immunisation	[89]
S1148−1156	SH	SARS-CoV-2	Natural infection	[74]
S1149−1204	SH-HR2	SARS-CoV-2	Natural infection	[46]
S1150−1157	SH	MERS-CoV	Immunisation	[87]
S1150−1156	SH-HR2	SARS-CoV-2	Natural infection	[47]
S1169−1188	HR2	SARS-CoV	Immunisation	[84]
S1169−1210	HR2-MP	SARS-CoV	Immunisation	[84]
S1205−1212	MP	SARS-CoV-2	Natural infection	[32]

¹Amino acid numbering refer to SARS-CoV-2 S.

²FP: fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connecting domain; SH, stem helix; HR2, heptad repeat 2; MP, membrane proximal.