Table 2.
Assessment of behavioral outcomes
| Cohort Study | Na | ASC symptoms | ADHD symptoms | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Instrument | Age (years) | Informant | Individuals within borderline/clinical range | Instrument | Age (years) | Informant | Individuals within borderline/clinical range | ||||
| n | % | n | % | ||||||||
| ALSPAC | 6200 | SCDC | 7 | Parents | 414 | 6.68 | DAWBA | 7 | Mothers | 120 | 1.9 |
| DNBC | 61,430 | SDQ | 7 | Mothers | 573 | 0.9 | SDQ | 7 | Mothers | 729 | 1.2 |
| Hospital diagnosis | 12.8 | Medical doctor | 970 | 1.6 | Hospital diagnosis | 12.8 | Medical doctor | 1289 | 2.1 | ||
| Generation R | 3904 | CBCL 1/2–5 | 6 | Parents | 299 | 7.7 | CPRS-R:S | 8 | Parents | 298 | 7.6 |
| GASPII | 489 | CBCL 1/2–5 | 4 | Parents | 63 | 12.9 | CBCL 1.5/5 | 4 | Parents | 50 | 10.2 |
| INMA | 1513 | CAST | 4.5 | Parents | 99 | 6.5 | ADHD-DSM-IV | 4.5 | Teachers | 175 | 11.6 |
| RHEA | 345 | CBCL 6/18 | 6 | Parents | 33 | 9.6 | CBCL 6/18 | 6 | Parents | 21 | 12.2 |
CAST childhood asperger syndrome test, CBCL child behaviour checklist,CPRS-R:S conner's parent rating scale revised short form, DAWBA development and well-being assessment, PDP pervasive developmental problems, SDQ strenghts and difficulties questionnaire, SCDC social communication disorders checklist
aNumber of children with data available on early acetaminophen exposure (prenatal or postnatal), at least one outcome (ASC or ADHD symptoms) and main covariates