Table 3.
Univariate and Multivariate COX Proportional Hazards Analysis of OS for Patients
| Characteristics | Total(N) | Univariate Analysis HR(95% CI) | P value | Multivariate Analysis HR(95% CI) | P value |
|---|---|---|---|---|---|
| Tumor status (With tumor vs Tumor free) | 450 | 6.211 (4.258–9.059) | < 0.001a | 6.064 (3.596–10.226) | <0.001a |
| Primary therapy outcome (PD&SD&PR vs CR) | 419 | 2.818 (2.004–3.963) | < 0.001a | 1.774 (1.136–2.771) | 0.012 |
| DSCC1 (High vs Low) | 504 | 1.531 (1.142–2.054) | 0.004 | 1.683 (1.071–2.643) | 0.024 |
| T stage (T2&T3&T4 vs T1) | 501 | 1.668 (1.184–2.349) | 0.003 | 1.237 (0.714–2.143) | 0.448 |
| N stage (N1&N2&N3 vs N0) | 492 | 2.606 (1.939–3.503) | < 0.001a | 1.631 (0.792–3.360) | 0.184 |
| M stage (M1 vs M0) | 360 | 2.111 (1.232–3.616) | 0.007 | 0.852 (0.355–2.048) | 0.721 |
| Pathologic stage (Stage II & Stage III & Stage IV vs Stage I) | 496 | 2.975 (2.188–4.045) | < 0.001a | 0.935 (0.424–2.062) | 0.867 |
| Gender (Male vs Female) | 504 | 1.060 (0.792–1.418) | 0.694 | ||
| Age (>65 vs ≤65) | 494 | 1.228 (0.915–1.649) | 0.171 | ||
| Race (White vs Asian & Black or African American) | 446 | 1.422 (0.869–2.327) | 0.162 | ||
| Anatomic neoplasm subdivision (Right vs Left) | 490 | 1.024 (0.758–1.383) | 0.878 | ||
| Anatomic neoplasm subdivision2 (Peripheral Lung vs Central Lung) | 182 | 0.913 (0.570–1.463) | 0.706 | ||
| Number pack years smoked (≥40 vs <40) | 345 | 1.038 (0.723–1.490) | 0.840 | ||
| Smoker (Yes vs No) | 490 | 0.887 (0.587–1.339) | 0.568 | ||
| TP53 status (Mut vs WT) | 499 | 1.254 (0.936–1.680) | 0.130 | ||
| KRAS status (Mut vs WT) | 499 | 1.087 (0.779–1.517) | 0.623 |
Note: aStatistically significant.
Abbreviations: PD, Progressive Disease; SD, Stable Disease; PR, Partial Response; CR, Complete Response; Mut, Mutant; WT, Wide Type; TPM, transcriptspermillionreads; CI, confidence interval; HR, hazard ratio.