Table 3.
Perspectives of Pregnant and Their Husbands with Different Pregnancy Histories
| Question | No Pregnancy History | p-valuea | Times of Pregnancy ≥1 | p-valuea | p-valueb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Pregnant Women (%) (n=41) | Husband (%) (n=28) | Pregnant Women (%) (n=74) | Husband (%) (n=63) | ||||||||
| Yes | No | Yes | No | Yes | No | Yes | No | ||||
| First category | |||||||||||
| (1) Have you ever heard of a drug clinical trial? | 16(39.02) | 25(60.98) | 13(46.43) | 15(53.57) | 0.541 | 42(56.76) | 32(43.24) | 32(50.79) | 31(49.21) | 0.485 | 0.104 |
| (2) Do you think drug clinical trials can increase the possibility of disease cure? | 40(97.56) | 1(2.44) | 20(71.43) | 8(28.57) | 0.002 | 67(90.54) | 7(9.46) | 49(77.78) | 14(22.22) | 0.039 | 0.661 |
| Second category | |||||||||||
| (1) Do you think it is necessary to use drugs when you are sick during pregnancy? | 40(97.56) | 1(2.44) | 25(89.29) | 3(10.71) | 0.149 | 68(91.89) | 6(8.11) | 53(84.13) | 10(15.87) | 0.158 | 0.178 |
| (2) Do you think it is necessary to develop drugs for pregnant women? | 41(100.0) | 0(0.00) | 25(89.29) | 3(10.71) | 0.032 | 68(91.89) | 6(8.11) | 51(80.95) | 12(19.05) | 0.059 | 0.049 |
| Third category | |||||||||||
| (1) Do you have any concerns about drugs provided for free in clinical trials? | 32(78.05) | 9(21.95) | 18(64.29) | 10(35.71) | 0.209 | 54(72.97) | 20(27.03) | 39(61.90) | 24(38.10) | 0.167 | 0.501 |
| (2) Do you think financial compensation will motivate you to participate in clinical trials? | 33(80.49) | 8(19.51) | 18(66.67) | 9(33.33) | 0.198 | 50(67.57) | 24(32.43) | 38(60.32) | 25(40.32) | 0.34 | 0.112 |
| Fourth category | |||||||||||
| (1) Do you think that it is more risky for pregnant women to participate in drug clinical trials when compared to others? | 40(97.56) | 1(2.44) | 27(96.43) | 1(3.57) | 0.783 | 67(90.54) | 7(9.46) | 53(84.13) | 10(15.87) | 0.256 | 0.026 |
| (2) Do you think that pregnant women who participate in drug clinical trials should be more protected for safety than others? | 33(80.49) | 8(19.51) | 17(60.71) | 11(39.29) | 0.071 | 50(67.57) | 24(32.43) | 38(60.32) | 25(39.68) | 0.378 | 0.236 |
| Fifth category | |||||||||||
| (1) Do you think pregnant women’s participation in clinical trials will lead to discrimination against themselves and/or their offsprings? | 11(26.83) | 30(73.17) | 5(17.86) | 23(82.14) | 0.386 | 24(32.43) | 50(67.57) | 12(19.05) | 51(80.95) | 0.076 | 0.63 |
| (2) Will you have the idea of terminating pregnancy because of participating in drug clinical trials? | 1(2.44) | 40(97.56) | 3(10.71) | 25(89.29) | 0.149 | 67(90.54) | 7(9.46) | 58(92.06) | 5(7.94) | 0.753 | 0.453 |
Notes: aStatistical difference between pregnant women and their spouses; bStatistical different pregnant history of pregnant and their spouses regarding the attitudes of drug clinical trials for pregnant women.