Table 1.
Characteristics and Outcomes of Study Population
| Characteristic* | Without Delirium N=300 |
With Delirium N=740 |
Entire Cohort N=1040 |
|---|---|---|---|
| Age at enrollment, years | 61 (51-71) | 63 (54-72) | 62 (53-72) |
| White race, N (%) | 275 (92%) | 671 (91%) | 946 (91%) |
| Male sex, N (%) | 192 (64%) | 435 (59%) | 627 (60%) |
| Education, years | 12 (12-14) | 12 (12-14) | 12 (12-14) |
| AHRQ Socioeconomic Index | 50 (47-53) | 50 (47-53) | 50 (47-53) |
| IQCODE-SF at enrollment | 3.0 (3.0-3.1) | 3.0 (3.0-3.2) | 3.0 (3.0-3.2) |
| Katz ADL at enrollment | 0 (0-1) | 0 (0-1) | 0 (0-1) |
| FAQ at enrollment | 0 (0-2) | 0 (0-3) | 0 (0-3) |
| Clinical Frailty Scale at enrollment, N (%) | |||
| ▪ Very fit | 9 (3%) | 22 (3%) | 31 (3%) |
| ▪ Well | 36 (12%) | 97 (13%) | 133 (13%) |
| ▪ Well, treated comorbid disease | 108 (36%) | 247 (33%) | 355 (34%) |
| ▪ Apparently vulnerable | 61 (20%) | 153 (21%) | 214 (21%) |
| ▪ Mildly frail | 46 (15%) | 94 (13%) | 140 (13%) |
| ▪ Moderately frail | 30 (10%) | 105 (14%) | 135 (13%) |
| ▪ Severely frail | 10 (3%) | 22 (3%) | 32 (3%) |
| Charlson comorbidity index | 2 (1-4) | 2 (1-4) | 2 (1-4) |
| Framingham stroke risk | 10 (6-14) | 10 (6-15) | 10 (6-15) |
| SOFA score at enrollment | 8 (6-10) | 9 (7-12) | 9 (7-11) |
| APACHE II at ICU admission | 20 (15-26) | 25 (19-31) | 24 (18-30) |
| ICU type, N (%) | |||
| ▪ Medical | 237 (79%) | 488 (66%) | 725 (70%) |
| ▪ Surgical | 63 (21%) | 252 (34%) | 315 (30%) |
| Severe sepsis on enrollment, N (%) | 138 (47%) | 418 (57%) | 556 (54%) |
| Delirium duration, days | 0 (0-0) | 4 (2-7) | 4 (2-7) |
| Coma, N (%) | 98 (33%) | 522 (71%) | 620 (60%) |
| ▪ Duration among exposed, days | 2 (1-4) | 3 (2-6) | 3 (1-6) |
| ICU length of stay, days | 2.8 (1.5-4.9) | 6.9 (3.8-14.1) | 5.0 (2.8-11.1) |
| In-hospital mortality, N (%) | 65 (22%) | 149 (20%) | 214 (21%) |
| 12-month mortality, N (%) | 113 (38%) | 305 (41%) | 418 (40%) |
*
Median (interquartile range) or N (percentage).
Participant characteristics and mortality outcomes of the cohort are displayed. Summary statistics are reported for non-missing values. Percents may not total 100 because of rounding.
Abbreviations: ADL, activities of daily living; AHRQ, Agency for Healthcare Research and Quality; APACHE, Acute Physiology and Chronic Health Evaluation; FAQ, Functional Activities Questionnaire; ICU, intensive care unit; IQCODE-SF, Short Form Informant Questionnaire on Cognitive Decline in the Elderly; SOFA, Sequential Organ Failure Assessment.