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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Anesth Analg. 2021 Nov 1;133(5):1152–1161. doi: 10.1213/ANE.0000000000005544

Table 2.

Relationship of Delirium Presence and Duration with Mortality

In-hospital Mortality the Following Day Hazard Ratio
(95% CI)
P-value
Delirium on a given day, yes vs. no 2.87 (1.32-6.21) 0.008

 Hypoactive delirium 3.35 (1.51-7.46) 0.003
 Hyperactive delirium 4.00 (0.49-32.51) 0.19
Post-discharge Mortality up to 1 Year Hazard Ratio
(95% CI)
P-value

Delirium presence, yes vs. no 1.01 (0.82-1.24) 0.95

 Hypoactive delirium 1.00 (0.81-1.23) 0.99
 Hyperactive delirium 0.78 (0.11-5.73) 0.81

Delirium duration, each additional day 0.99 (0.97-1.01) 0.56

 Hypoactive delirium 1.00 (0.98-1.02) 0.74
 Hyperactive delirium 0.99 (0.82-1.19) 0.89

The results of Cox proportional hazard analyses testing the independent associations between delirium on a given day and risk of death the following day for patients in the hospital are displayed, including for motoric subtypes. Delirium on a given day, in particular hypoactive delirium, was independently associated with approximately 3-fold increased risk of death the following day. In addition, the results of Cox proportional hazard analyses (restricted to those who survived to hospital discharge) testing the independent associations between delirium presence and duration in the hospital and risk of death after hospital discharge up to 1 year are shown. Neither delirium presence nor duration, regardless of subtype, was associated with post-discharge mortality up to 1 year. Analyses are adjusted for coma and baseline and daily hospital course covariates.