Table 3.
Performance of mNGS and the Conventional Test in the Diagnosis of Pulmonary Fungal Infections
| Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | P value | P value | |
|---|---|---|---|---|---|---|
| mNGS (biopsy) | 80.0a,b (65.0–89.9) | 91.8A,B (81.2–96.9) | 87.8 (73.0–95.4) | 86.2 (74.8–93.1) | 0.754a | 0.388A |
| mNGS (balf) | 84.4a,c (69.9–93.0) | 85.3A,C (73.3–92.6) | 80.9 (66.3–90.4) | 88.1 (76.5–94.7) | 0.002b | 0.774B |
| Conventional test | 44.44b,c (30.0–59.9) | 88.52B,C (77.2–94.9) | 74.1 (53.4–88.1) | 68.4 (56.8–78.1) | 0.0003c | 0.774C |
Notes: Sensitivity: a, biopsy-mNGS vs BALF-mNGS; b, biopsy-mNGS vs conventional test; c, BALF-mNGS vs conventional test. Specificity: A, biopsy-mNGS vs BALF-mNGS; B, biopsy-mNGS vs conventional test; C, BALF-mNGS vs conventional test.
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval.