Table 6.
Results of the 32 Patients with Matching mNGS Results
| Patient ID | mNGS (Biopsy, Fungus Detected) | mNGS (Balf, Fungus Detected) | Final Clinical Diagnosis | mNGS (Biopsy) /mNGS (BAL) | Matching Level |
|---|---|---|---|---|---|
| 1 | Rhizopus microsporus (1337) Aspergillus oryzae (3) |
Rhizopus microsporus (23) | Pulmonary fungal infections | 58 | Partial match |
| 11 | Aspergillus oryzae (1257) Aspergillus flavus (1146) |
Aspergillus oryzae (4) Aspergillus flavus (1) |
Pulmonary fungal infections | 314 | Complete match |
| 16 | Scedosporium (4) | Scedosporium (127) | Pulmonary fungal infections | 0.03 | Complete match |
| 24 | Aspergillus oryzae (155) Aspergillus flavus (102) |
Aspergillus oryzae (11) Aspergillus flavus (6) |
Pulmonary fungal infections | 14 | Complete match |
| 27 | Aspergillus nidulans (279,595) Rhizomucor pusillus (3861) Aspergillus versicolor (183) Aspergillus calidoustus (175) Aspergillus ustus (137) |
Aspergillus nidulans (234) Rhizomucor pusillus (6) |
Pulmonary fungal infections | 1195 | Partial match |
| 29 | Aspergillus fumigatus (922) Aspergillus fischer (5) |
Aspergillus fumigatus (207) | Pulmonary fungal infections | 4 | Partial match |
| 31 | Rhizomucor pusillus (5320) | Rhizomucor pusillus (2) | Pulmonary fungal infections | 2660 | Complete match |
| 41 | Aspergillus oryzae (863) Aspergillus flavus (207) | Aspergillus oryzae (9) | Pulmonary fungal infections | 96 | Partial match |
| 45 | Coprinopsis cinerea (1380) | Coprinopsis cinerea (49) | Pulmonary fungal infections | 28 | Complete match |
| 51 | Aspergillus fumigatus (41,388) | Aspergillus fumigatus (74) | Pulmonary fungal infections | 559 | Complete match |
| 52 | Pneumocystis jirovecii (12,496) | Pneumocystis jirovecii (6566) | Pulmonary fungal infections | 2 | Complete match |
| 55 | Aspergillus oryzae (46) | Aspergillus oryzae (4) Aspergillus (5) | Pulmonary fungal infections | 12 | Partial match |
| 57 | Pneumocystis jirovecii (360) | Pneumocystis jirovecii (452) | Pulmonary fungal infections | 0.8 | Complete match |
| 59 | Rhizopus microsporus (522,197) Mucor (5755) | Rhizopus microsporus (159) | Pulmonary fungal infections | 3284 | Partial match |
| 65 | Aspergillus (4) | Aspergillus (7) | Pulmonary fungal infections | 0.6 | Complete match |
| 66 | Aspergillus (3) | Aspergillus flavus (13) | Pulmonary fungal infections | 0.2 | Complete match |
| 68 | Rhizopus microsporus (299,937) Mucor (8925) Syncephalastrum (21) |
Rhizopus microsporus (352) Mucor (8) Aspergillus (5) |
Pulmonary fungal infections | 852 | Partial match |
| 75 | Aspergillus fumigatus (5938) | Aspergillus fumigatus (1178) | Pulmonary fungal infections | 5 | Complete match |
| 78 | Aspergillus flavus (2) | Aspergillus flavus (3) | Pulmonary fungal infections | 0.7 | Complete match |
| 79 | Aspergillus oryzae (150) | Aspergillus oryzae (21) Aspergillus (32) |
Pulmonary fungal infections | 7 | Partial match |
| 80 | Lichtheimia ramosa (196) Rhizomucor pusillus (2) |
Lichtheimia ramosa (166) Rhizomucor pusillus (39) |
Pulmonary fungal infections | 1.2 | Complete match |
| 82 | Aspergillus flavus (488) | Aspergillus (123) | Pulmonary fungal infections | 4 | Complete match |
| 83 | Lichtheimia ramosa (186) | Lichtheimia ramosa (149) | Pulmonary fungal infections | 1.2 | Complete match |
| 84 | Rhizomucor pusillus (880) | Rhizomucor pusillus (9) | Pulmonary fungal infections | 98 | Complete match |
| 93 | Pneumocystis jirovecii (321) | Pneumocystis jirovecii (4) | Pulmonary fungal infections | 80.2 | Complete match |
| 96 | Aspergillus oryzae (1618) Aspergillus flavus (1344) |
Aspergillus oryzae (330) Aspergillus flavus (266) |
Pulmonary fungal infections | 4.9 | Complete match |
| 97 | Pneumocystis jirovecii (161,687) | Pneumocystis jirovecii (12,504) | Pulmonary fungal infections | 12.9 | Complete match |
| 99 | Pneumocystis jirovecii (14,006) | Pneumocystis jirovecii (2160) | Pulmonary fungal infections | 6.5 | Complete match |
| 100 | Rhizopus oryzae (42) | Rhizopus oryzae (2) | Pulmonary fungal infections | 21 | Complete match |
| 102 | Cryptococcusmans (557) | Cryptococcusmans (12) | Pulmonary fungal infections | 46.4 | Complete match |
| 103 | Aspergillus fumigatus (28) | Aspergillus fumigatus (20) | Pulmonary fungal infections | 1.4 | Complete match |
| 106 | Aspergillus oryzae (1182) | Aspergillus oryzae (48) Pneumocystis jirovecii (6) | Pulmonary fungal infections | 24.6 | Partial match |
Abbreviation: mNGS/mNGS (BALF), mNGS (Biopsy) most detected fungal reads/mNGS (BAL) most detected fungal reads.