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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Hepatology. 2021 Jul 26;74(5):2436–2451. doi: 10.1002/hep.31994

Fig. 7. Schematic diagram on the significance of selected miRNAs in AH pathogenesis.

Fig. 7

Hepatic and serum expression of miR-30b-5p, miR-20a-5p, miR-26b-5p, and miR-146a-5p are significantly reduced in patients with alcoholic hepatitis. These miRNAs regulate genes, RRM2, CCND1, and CCND2, which are involved in DNA synthesis and cell-cycle progression, in response to liver injury. Higher expression of these miRNAs, suggestive of a diminished capacity in DNA synthesis and cell-cycle progression, predicts short-term mortality in AH patients.