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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Osteoarthritis Cartilage. 2021 Aug 28;29(11):1549–1563. doi: 10.1016/j.joca.2021.08.008

Figure 4. Effect of HF diet and voluntary wheel running on proximal tibia subchondral and trabecular bone density and morphology as measured by micro-CT.

Figure 4.

A. Trabecular and medial compartment subchondral bone mineral density (BMD) was increased by a HF diet, especially in sedentary mice. B. Trabecular bone morphology was largely unaffected by a HF diet and voluntary wheel running. An exception was the trabecular connectivity density, which was reduced by a HF diet in sedentary but not exercise mice. BV=bone volume, TV=total volume. Data points are values for individual animals, and bars are mean +/− 95% CI. Significant differences between groups are indicated by bars that do not share a common letter (2-factor ANOVA, p≤0.05, followed by Fisher’s LSD post-hoc, p<0.05).