Table 3.
Crude and adjusted risk and risk ratios of prolonged opioid use comparing patients who received preoperative gabapentinoids to those who did not (referent).
| Population | Exposure Status | Number of Patients | Observed Risk (95% CI) | Number of Patients after Trimming | Adjusteda Risk (95% CI) | Adjusteda Risk Ratio (95% CI) |
|---|---|---|---|---|---|---|
| Full Population | Overall | 13,958 | 0.91% (0.77,1.08) | 11,303 | 0.87% (0.70,1.09) | 1.19 (0.67,2.12) |
| Gabapentinoid=1 | 2,931 | 1.19% (0.86,1.66) | 2,491 | 1.00% (0.59,1.68) | ||
| Gabapentinoid=0 | 11,027 | 0.83% (0.68,1.02) | 8,812 | 0.84% (0.66,1.06) | ||
| Surgeries with >30% Exposed | Overall | 2,626 | 0.62% (0.38,1.01) | 2,410 | 0.70% (0.41,1.21) | 1.01 (0.30,3.33) |
| Gabapentinoid=1 | 1,587 | 0.76% (0.44,1.34) | 1,481 | 0.70% (0.39,1.28) | ||
| Gabapentinoid=0 | 1,039 | 0.39% (0.15,1.05) | 929 | 0.70% (0.25,1.98) | ||
| Outpatient Visit and Rx in Prior 182 Days | Overall | 5,084 | 1.63% (1.32,2.02) | 4,192 | 1.85% (1.42,2.40) | 1.06 (0.57,1.99) |
| Gabapentinoid=1 | 1,128 | 1.86% (1.22,2.84) | 927 | 1.94% (1.11,3.36) | ||
| Gabapentinoid=0 | 3,956 | 1.57% (1.22,2.01) | 3,264 | 1.82% (1.35,2.45) |
a
Stabilized Inverse probability of treatment weights (IPTW) were calculated within each population after conducting 1% asymmetric trimming to adjust for baseline confounding.