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Interaction of tau, α-syn, Aβ, iron, and GSK3β. (1) The synergistic effect of α-syn and Aβ. (2) Iron promotes the overexpression of α-syn and Aβ. (3) Iron promotes the activation of GSK3β. (4) α-Syn and Aβ can promote an increase in GSK3β, which can, in turn, promote the expression of α-syn and Aβ. (5) GSK3β promotes the phosphorylation of tau.
