Table 2.
Decreased lipids in SH-SY5Y cells after the treatment with olives leaves-sea sand adsorbate (OL-SS) at 40 μg/mL in comparison to control conditions after 24 h.
| Lipid name | Ionization mode | MSI level | Fold change | p-value | FDR |
|---|---|---|---|---|---|
| TG 52:4|TG 18:1_18:1_16:2 | ESI (+) | 2a | 0.314 | 5.83E-07 | 0.01187 |
| PG 40:7|PG 18:1_22:6 | ESI (–) | 2a | 0.321 | 2.24E-09 | 0.02473 |
| TG 58:7|TG 18:0_18:1_22:6 | ESI (+) | 2a | 0.334 | 1.51E-06 | 0.01187 |
| TG 54:3 | ESI (+) | 1 | 0.337 | 1.90E-05 | 0.01187 |
| TG 52:2 | ESI (+) | 1 | 0.353 | 1.88E-05 | 0.01187 |
| TG 60:7|TG 18:1_18:1_24:5 | ESI (+) | 2a | 0.357 | 1.64E-05 | 0.01187 |
| TG 56:8_B | ESI (+) | 2b | 0.367 | 9.79E-07 | 0.01187 |
| TG 50:3_B | ESI (+) | 2b | 0.370 | 7.41E-08 | 0.01187 |
| TG 50:1 | ESI (+) | 1 | 0.387 | 2.35E-05 | 0.01187 |
| TG 53:3 | ESI (+) | 2b | 0.390 | 2.60E-06 | 0.01187 |
| TG 56:7_B | ESI (+) | 1 | 0.391 | 2.42E-08 | 0.01187 |
| TG 48:2 | ESI (+) | 1 | 0.394 | 1.13E-06 | 0.01187 |
| TG 58:9 | ESI (+) | 2b | 0.394 | 1.01E-05 | 0.01187 |
| TG 46:1 | ESI (+) | 2b | 0.400 | 3.37E-07 | 0.01187 |
| TG 55:3 | ESI (+) | 2b | 0.402 | 1.68E-05 | 0.01187 |
| TG 50:2 | ESI (+) | 1 | 0.415 | 1.65E-06 | 0.01187 |
| TG 58:8 | ESI (+) | 1 | 0.416 | 2.55E-07 | 0.01187 |
| TG 48:1 | ESI (+) | 1 | 0.420 | 1.01E-07 | 0.01187 |
| TG 52:3 | ESI (+) | 1 | 0.420 | 6.11E-07 | 0.01187 |
| TG 51:3 | ESI (+) | 2b | 0.424 | 3.37E-06 | 0.01187 |
| TG 54:2 | ESI (+) | 2b | 0.427 | 8.63E-06 | 0.01187 |
| TG 50:3_A | ESI (+) | 1 | 0.430 | 2.81E-06 | 0.01187 |
| TG 58:5 | ESI (+) | 1 | 0.438 | 2.08E-05 | 0.01187 |
| TG 56:4 | ESI (+) | 1 | 0.443 | 1.41E-05 | 0.01187 |
| TG 56:5_B | ESI (+) | 2b | 0.446 | 2.36E-06 | 0.01187 |
| TG 54:5_B | ESI (+) | 2b | 0.448 | 9.64E-07 | 0.01187 |
| TG 54:4 | ESI (+) | 1 | 0.450 | 1.04E-06 | 0.01187 |
| TG 56:3 | ESI (+) | 1 | 0.475 | 1.96E-05 | 0.01187 |
| TG 51:2 | ESI (+) | 2b | 0.482 | 1.59E-06 | 0.01187 |
| TG 58:4 | ESI (+) | 1 | 0.491 | 1.02E-05 | 0.01187 |
| TG 52:4 | ESI (+) | 2b | 0.500 | 5.33E-06 | 0.01187 |
| TG 48:0 | ESI (+) | 2b | 0.510 | 2.37E-06 | 0.01757 |
| TG O-52:2|TG O-18:1_16:0_18:1 | ESI (+) | 2a | 0.514 | 2.44E-04 | 0.01187 |
| TG 52:1 | ESI (+) | 1 | 0.522 | 6.19E-06 | 0.01187 |
| TG 51:1 | ESI (+) | 2b | 0.546 | 1.28E-03 | 0.01187 |
| TG 60:6 | ESI (+) | 2b | 0.553 | 6.85E-05 | 0.01187 |
| GlcCer d42:2 | ESI (+) | 2b | 0.554 | 1.10E-05 | 0.01187 |
| TG 58:6 | ESI (+) | 1 | 0.559 | 6.77E-06 | 0.01187 |
| TG 55:2 | ESI (+) | 2b | 0.560 | 4.40E-05 | 0.01187 |
| TG 60:3 | ESI (+) | 2b | 0.564 | 6.84E-04 | 0.01187 |
| TG 56:5_C | ESI (+) | 2b | 0.575 | 1.25E-06 | 0.01187 |
| TG 56:6 | ESI (+) | 1 | 0.580 | 2.76E-06 | 0.01187 |
| TG 54:1 | ESI (+) | 1 | 0.588 | 6.53E-06 | 0.01187 |
| FA 20:2 | ESI (–) | 1 | 0.593 | 2.52E-03 | 0.02473 |
| PG 36:2|PG 18:1_18:1 | ESI (–) | 2a | 0.598 | 1.51E-05 | 0.02473 |
| TG 56:2 | ESI (+) | 2b | 0.599 | 1.64E-05 | 0.01187 |
| TG 58:3 | ESI (+) | 2b | 0.609 | 3.48E-06 | 0.01187 |
| NAE 14:0 | ESI (+) | 2a | 0.622 | 4.87E-06 | 0.01187 |
| TG 60:5 | ESI (+) | 2b | 0.626 | 5.48E-05 | 0.01187 |
| TG 58:2 | ESI (+) | 2b | 0.627 | 2.97E-04 | 0.01187 |
| TG 46:0 | ESI (+) | 2b | 0.630 | 4.36E-04 | 0.01187 |
| TG 60:4 | ESI (+) | 2b | 0.639 | 3.55E-06 | 0.01187 |
| TG 62:7|TG 18:1_22:3_22:3 | ESI (+) | 2a | 0.650 | 2.27E-04 | 0.01187 |
| PE o-36:5|PE o-16:1_20:4 | ESI (–) | 1 | 0.653 | 2.65E-06 | 0.02473 |
| PC p-36:4/PC o-36:5 | ESI (–) | 2b | 0.665 | 9.25E-06 | 0.02473 |
MSI, Metabolomics Standard Initiative identification; FDR, False discovery rate; FA, fatty acids; GlcCer, Glucosylceramide; NAE, N-Acylethanolamine; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; TG, triacylglycerol. Letters after lipid name indicate that one specific isomer of those contained in the database is identified.
Significance is determined using a Fold Change threshold ≤ 0.67 and a Mann–Whitney U-test with FDR < 0.05.