Table 1.

Demographic and clinical characteristics of drug-naïve patients with major depressive disorder (MDD) and healthy controls (HCs)

	Drug-naïve MDD patients (N=71)	HCs (N=111)	Significance (p-value)
Age (years)	40.97±12.43	39.11±13.51	0.350
Sex (male/female)	17/54	38/73	0.133
Education level			0.78
Elementary and middle school	15	16
High school or college/university	53	83
Above graduate school	3	12
TICV (cm3)	1426.35±116.08	1452.26±167.03	0.0219
Illness duration (months)	25.79±37.46	-	N/A
HDRS score	18.28±4.99	1.53±1.85	<0.0001*

Significance was evaluated using a two-sample t-test.

^*denotes significance.

TICV, total intracranial volume; HDRS, Hamilton Depression Rating Scale