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. 2021 Oct 11;12:732933. doi: 10.3389/fimmu.2021.732933

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Copyright © 2021 Zhang, Yang, Li and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NLRP3 inflammasome connects innate and adaptive immunity in autoimmune diseases. NLRP3 inflammasome is activated abnormally in autoimmune diseases. In the upstream process, exogenous pathogen irritants and endogenous danger signals initiate assembly of NLRP3 inflammasome. In the upstream process, IL-1β, IL-18, and pyroptosis, which are modulated by NLRP3 inflammasome, regulate adaptive immune response. Namely, NLRP3 inflammasome might participate in the transition from innate immunity to adaptive immunity in the pathogenesis of autoimmune diseases as a checkpoint. The detailed process of activation, assembly, regulation, and effects on adaptive immunity are shown in Figure 2 .