TABLE 1.
Detection by ELISA of IgG seroconversion (sc) and IgM antibodies specific for rMXV and rNV in volunteers and in natural outbreaks of gastroenteritis
| Genogroup | Samples | No. of sera with the following result/no. tested:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IgM+a for:
|
IgG sc+ for:
|
IgM+ and IgGsc+ for:
|
IgM+ and IgGsc− for:
|
IgGsc+ and IgM− for:
|
IgGsc− and IgM− for:
|
||||||||
| rMXV | rNV | rMXV | rNV | rMXV | rNV | rMXV | rNV | rMXV | rNV | rMXV | rNV | ||
| I | NV-inoculated volunteers (paired sera) | 0/9 | 9/9 | 1/9 | 9/9 | 0/9 | 9/9 | 0/9 | 0/9 | 1/9 | 0/9 | 8/9 | 0/9 |
| Erie County outbreak (paired sera) | 3/16 | 15/16 | 10/16 | 13/16 | 0/16 | 12/16 | 2/16 | 3/16 | 9/16 | 1/16 | 2/16 | 0/16 | |
| II | HV-inoculated volunteers (paired sera) | 2/4 | 0/4 | 4/4 | 1/4 | 2/4 | 0/4 | 0/4 | 0/4 | 2/4 | 3/4 | 0/4 | 1/4 |
| SMV-inoculated volunteers (convalescent-phase sera) | 3/3 | 0/3 | NAe | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| SMV outbreak (paired sera) | 11/21 | 0/21 | 4/21 | 1/21 | 2/21 | 0/21 | 9/21 | 0/21 | 2/21 | 1/21 | 8/21 | 20/21 | |
| TNV outbreak (paired sera) | 2/2 | 0/2 | 2/2 | 0/2 | 2/2 | 0/2 | 0/2 | 0/2 | 0/2 | 0/2 | 0/2 | 2/2 | |
| MXV outbreak (paired sera)b | 4/4 | 0/4 | 4/4 | 1/4 | 4/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 0/4 | 3/4 | |
| UMMC-UC outbreak (paired sera)c | 2/5 | 0/5 | 0/5 | 1/5 | 0/5 | 0/5 | 2/5 | 0/5 | 0/5 | 1/5 | 3/5 | 4/5 | |
| UMMC-UC outbreak (convalescent-phase sera) | 4/8 | 0/8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Unknown | Rhode Island outbreak (paired sera) | 7/13 | 0/13 | 2/13 | 1/13 | 1/13 | 0/13 | 6/13 | 0/13 | 1/13 | 1/13 | 5/13 | 12/13 |
| Otherd | Rotavirus (paired sera) | 0/6 | 0/6 | 0/6 | 0/6 | 0/6 | 0/6 | 0/6 | 0/6 | 0/6 | 0/6 | 6/6 | 6/6 |
| Astrovirus (paired sera) | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 4/4 | 4/4 | |
A serum positive for IgM is one in which the IgM antibody titer is ≥1:25 in a single sample.
The outbreak was confirmed to be due to MXV.
Acute-phase sera were collected late.
All sera from patients with rotavirus and astrovirus infections had IgG titers to rNV and rMXV in their acute- and convalescent-phase sera.
NA, not applicable.