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. 2021 Oct 11;9:737872. doi: 10.3389/fcell.2021.737872

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Copyright © 2021 Shaw, Tóth, Király, Arianti, Csomós, Póliska, Vámos, Korponay-Szabó, Bacso, Győry, Fésüs and Kristóf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Irisin upregulated similar gene-sets that encode for cytokines in subcutaneous (SC) and deep-neck (DN) depots of human neck area adipocytes. SC and DN preadipocytes were differentiated and treated as in Figure 1. (A) Volcano plot showing each of the upregulated genes in SC (red) and DN (blue) depots upon irisin treatment; the highest upregulated genes are listed separately, (B) Venn-diagram illustrating the genes commonly upregulated by irisin treatment in SC and DN depots. Gephi illustrations highlighting the most important pathways and the interaction of genes upregulated by irisin treatment in SC (C) and DN (D) derived adipocytes.