TABLE 1.

Pathways of significantly upregulated genes upon irisin treatment during differentiation of subcutaneous (SC) and deep-neck (DN) derived adipocytes.

Panther reactome pathways	Gene name	FDR
SC Irisin upregulated
IkBA variant leads to EDA-ID	NFKBIA, NFKB2	4.49 × 10–2
Cytokine signaling in immune system	IL6, NFKBIA, JUNB, IL32, SOD2, MT2A, NFKB2, CXCL2, CCL2, IL15RA, IL18, IL34, ICAM1, CXCL1, RELB, BIRC3	5.23 × 10–8
Interleukin-10 signaling	IL6, CXCL2, CCL2, IL18, ICAM1, CXCL1	1.65 × 10–6
Class A/1 (Rhodopsin like receptors)	CXCL3, CXCL5, CX3CL1, CXCL2, CCL2, CXCL1	3.5 × 10–2
Interleukin-4 and Interleukin-13 signaling	IL6, JUNB, CCL2, IL18, ICAM1	2.3 × 10–3
DN Irisin Upregulated
Response to metal ions	MT2A, MT1E, MT1F	4.74 × 10–3
Class A/1 (Rhodopsin like receptors)	CCL11, CXCL3, CXCL5, CX3CL1, CXCL2, CCL2, CXCL1	1.85 × 10–2
Cytokine signaling in immune system	IL6, CCL11, ITGB2, NFKBIA, JUNB, IL32, SOD2, MT2A, NFKB2, IL7R, CXCL2, CCL2, IL34, ICAM1, HCK, CXCL1, RELB, BIRC3	5.55 × 10–8
Interleukin-4 and Interleukin-13 signaling	IL6, CCL11, ITGB2, JUNB, CCL2, ICAM1	6.33 × 10–4
G-alpha (i) signaling events	CXCL3, CXCL5, CX3CL1, ADCY4, RGS16, CXCL2, CXCL1	5.07 × 10–2

Genes commonly upregulated in both SC and DN area adipocytes are in bold character.

CXCL1 was the highest upregulated gene in both SC and DN area adipocytes.

FDR, false discovery rate.