TABLE 5.

A comparison of target molecules in treatment of fibrosis using modern therapy vs. cannabis treatment.

A single-component medication:	Cannabis
The mechanism of action of asingle-component medication vs. cannabis
• TGF-β inhibitor (Pirfenidone) • PDGFR antagonist (Imatinib) • TNF inhibitor (Talidomide, Etanercept, Belimumab) • IL-1 antagonist (Anakinra, Rilonacept) • IFN-γ stimulant (Actimmune) • MMP/TIMP inhibitor (Marimastat) • mTOR inhibitor (Rapamycin) • JAK-STAT inhibitor (Ruxolitinib) • PI3K-Akt inhibitor (Omipalisib) • MAPK inhibitor (MMI-0100) • NF-kB inhibitor (IMD-1041) • miR-21 inhibitor (Anti-miR-21)	• TGF-β inhibitor • TNF inhibitor • MMP/TIMP inhibitor
The mechanism of action of a multi-component medication vs. cannabis
A multi-component medication:	Cannabis
• TGF-pc/MMP-2c inhibitor (Fuzhenghuayu) • TNF-α/TGF-β inhibitor (Danggui-Buxue-Tang)	• TGF-β1/Smad2 inhibitor