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. 2021 Oct 11;9:753931. doi: 10.3389/fcell.2021.753931

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Copyright © 2021 Zheng, Song, Guo, Su, Chen, Yang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of altered lncRNA expression patterns and their biological effects in intervertebral disk degeneration. lncRNA, long non-coding RNA; ECM, extracellular matrix; MMP, matrix metallopeptidase; MAPK, mitogen-activated protein kinase; SMAD3, SMAD family member 3; LEF1, lymphoid enhancing factor-1; CCND1, cyclin D1; ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4; TRAF6, tumor necrosis factor receptor-associated factor 6; Notch1, Notch Receptor 1; Bcl-2, B cell lymphoma 2; ATG5, autophagy-related gene 5.