TABLE 2.

lncRNA/miRNA/mRNA networks in rheumatoid arthritis and ankylosing spondylitis.

	Species	Diseases	Region	lncRNA	Change	miRNA	Expression	Target gene	Change	Functions	References
(1)	Rat	RA	Synovial tissues	PVT1	Up	miR-543	Down	SCUBE2	Up	Cell proliferation and apoptosis	Wang et al., 2020
(2)	Human	RA	Synovial tissues	LINC-PINT	Down	miR-155-5p	Up	SOCS1	Down	Cell proliferation and invasion	Wang and Zhao, 2020
(3)	Human	RA	Serum	HIX003209	Up	miR-6089	Down	TLR4	Up	Inflammation	Yan et al., 2019
(4)	Human	AS	Serum, fibroblast-like synovial cells	lncRNA MEG3	Down	miR-146a	Up	–	–	Inflammation	Li Y. et al., 2020
(5)	Human	AS	Peripheral blood mononuclear cells	H19	Up	miR675-5p/miR22-5p	miR675-5p up; miR22-5p down	VDR	Up	Inflammation	Zhang et al., 2020f

AS, ankylosing spondylitis; MEG3, maternally expressed gene 3; PINT, p53-induced transcript; PVT1, plasmacytoma variant translocation 1; RA, rheumatoid arthritis; SCUBE2, signal peptide-CUB-EGF-like containing protein 2; SOCS1, cytokine signaling 1.