TABLE 3.

circRNA/miRNA/mRNA networks in rheumatoid arthritis.

	Species	Diseases	Region	circRNA	Change	miRNA	Change	Target gene	Change	Functions	References
(1)	Human	RA	Synovial tissues	hsa_circ_0001859	Up	miR-204/211	Down	ATF2	Up	Inflammation	Li B. et al., 2018
(2)	Mice	RA	Peripheral blood mononuclear cells	circRNA_09505	Up	miR-6089	Down	AKT1/NF-κB signaling pathway	Up	Inflammation	Yang J. et al., 2020

AKT1, threonine kinase 1; ATF2, activating transcription factor 2; NF-κB: nuclear factor κB; RA, rheumatoid arthritis.