Table 3.

Univariate and multivariate COX regression analysis of prognostic factors for overall survival in primary cohort.

Variables	No. of patients	Univariate P value	Multivariate analysis*		Multivariate analysis#
			HR (95% CI)	P value	HR (95% CI)	P value
Age (≥65 vs. <65)	439/1,228	<0.001	1.232 (1.049–1.446)	0.011	1.232 (1.049–1.446)	0.011
Gender (Male vs. female)	1,154/513	0.387
Preoperative albumin (≥35 vs. <35 g/L)	1,487/180	0.600
Comorbidities (Yes vs. No)	444/1,223	0.076	0.991 (0.839–1.173)	0.920	0.992 (0.838–1.173)	0.921
Surgery approach (Laparoscopic vs. Open)	189/1,478	0.001	0.829 (0.645–1.065)	0.143	0.830 (0.646–1.066)	0.144
Gastrectomy (Total vs. Partial)	457/1,210	<0.001	1.160 (0.993–1.355)	0.061	1.159 (0.992–1.354)	0.063
Lymphadenectomy (≥D2 vs. <D2)	1,618/46	0.692
Resection of other organs (Yes vs. No)	67/1,600	0.434
Perioperative blood transfusion (Yes vs. No)	262/1,405	<0.001	1.192 (0.987–1.428)	0.067	1.199 (0.993–1.447)	0.059
Tumor size (≥5 vs. <5 cm)	914/753	<0.001	1.436 (1.209–1.706)	<0.001	1.434 (1.207–1.703)	<0.001
Macroscopic type (Bormann 3–4 vs. 0–2)	611/1,056	<0.001	1.017 (0.870–1.189)	0.833	1.015 (0.868–1.186)	0.854
Histological grade (G3/G4 vs. G1/G2)	1,149/518	<0.001	1.192 (1.011–1.406)	0.037	1.190 (1.009–1.403)	0.039
Depth of invasion (T4 vs. T1/2/3)	801/866	<0.001	1.903 (1.609–2.252)	<0.001	1.903 (1.609–2.252)	<0.001
Nodal involvement (N+ vs. N0)	1,142/525	<0.001	2.239 (1.839–2.726)	<0.001	2.247 (1.845–2.736)	<0.001
Adjuvant chemotherapy (Yes vs. No)	838/829	0.918	0.806 (0.698–0.931)	0.003	0.808 (0.699–0.933)	0.004
SCs (Yes vs. No)	168/1,449	0.002	1.442 (1.160–1.791)	0.001
ICs (Yes vs. No)	111/1,556	0.003			1.455 (1.125–1.881)	0.004
NICs (Yes vs. No)	71/1,596	0.072			1.355 (0.977–1.878)	0.068

*Multivariate analysis describing the prognosis of SCs for gastric cancer patients.

^#Multivariate analysis describing the prognosis of ICs and NICs for gastric cancer patients.

The bold values indicate the main objects of this study.