Table 4.

Univariate and multivariate COX regression analysis of prognostic factors for overall survival in PSM cohort.

Variables	No. of patients	Univariate P value	Multivariate analysis*		Multivariate analysis#
			HR (95% CI)	P value	HR (95% CI)	P value
Age (≥65 vs. <65)	199/304	0.008	1.275 (0.983–1.654)	0.067	1.278 (0.985–1.658)	0.064
Gender (Male vs. female)	380/123	0.289
Preoperative albumin (≥35 vs. <35 g/L)	443/60	0.944
Comorbidities (Yes vs. No)	169/334	0.198
Surgery approach (Laparoscopic vs. Open)	61/442	0.009	0.751 (0.479–1.177)	0.212	0.748 (0.477–1.174)	0.207
Gastrectomy (Total vs. Partial)	152/351	0.002	1.085 (0.823–1.431)	0.563	1.080 (0.818–1.425)	0.589
Lymphadenectomy (≥D2 vs. <D2)	500/3	0.740
Resection of other organs (Yes vs. No)	20/483	0.076	1.059 (0.582–1.928)	0.851
Perioperative blood transfusion (Yes vs. No)	95/408	<0.001	1.352 (1.006–1.818)	0.045	1.384 (1.028–1.863)	0.032
Tumor size (≥5 vs. <5 cm)	297/206	<0.001	1.483 (1.071–2.054)	0.018	1.478 (1.069–2.044)	0.018
Macroscopic type (Bormann 3–4 vs. 0–2)	191/312	<0.001	1.070 (0.800–1.432)	0.648	1.062 (0.794–1.421)	0.686
Histological grade (G3/G4 vs. G1/G2)	333/170	0.001	1.366 (1.017–1.834)	0.038	1.360 (1.012–1.826)	0.041
Depth of invasion (T4 vs. T1/2/3)	247/256	<0.001	1.552 (1.161–2.073)	0.003	1.547 (1.158–2.068)	0.003
Nodal involvement (N+ vs. N0)	335/168	<0.001	2.378 (1.707–3.314)	<0.001	2.403 (1.724–3.349)	<0.001
Adjuvant chemotherapy (Yes vs. No)	238/265	0.149	0.750 (0.580–0.970)	0.028	0.754 (0.583–0.974)	0.031
SCs (Yes vs. No)	168/335	0.013	1.529 (1.175–1.990)	0.002
ICs (Yes vs. No)	111/392	0.015			1.567 (1.175–2.089)	0.002
NICs (Yes vs. No)	71/432	0.193			1.386 (0.978–1.963)	0.067

*Multivariate analysis describing the prognosis of SCs for gastric cancer patients.

^#Multivariate analysis describing the prognosis of ICs and NICs for gastric cancer patients.

The bold values indicate the main objects of this study.