TABLE 2.

Gene set enrichment analysis for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) versus uninfected differential expression genes using NanoString's nCounter PanCancer Progression Panel custom gene sets

Gene set name	Genes n	Direction of change	Two-sided directional		Non-directional
			p-value	FDR	p-value	FDR
Blood coagulation	47	Up	4.30	3.56	11.62	11.06
Angiogenesis response	56	Up	2.30	1.74	22.35	21.31
Hypoxia response	36	Up	1.89	1.43	7.35	6.97
Positive regulation of angiogenesis	35	Down	0.98	0.79	8.38	7.94
Negative regulation of angiogenesis	17	Up	0.51	0.42	1.62	1.35
Fibrosis	9	Up	0.27	0.23	1.05	0.96
Regulation of angiogenesis	11	Down	0.08	0.08	1.12	0.96

All p-values and false discovery rates (FDRs) reported as −log₁₀ value. Gene sets highlighted in green indicate biological processes identified by gene set enrichment analysis to be differentially upregulated in SARS-CoV-2 infected lungs versus uninfected samples with FDR <0.05.