Table 2.
Elevation of neutrophil-related factors in NASH patients and experimental NASH models.
| Level change in NASH | Location | NASH induction model | Reference | |
|---|---|---|---|---|
| MPO | ↑ | Liver and plasma | NASH patients | (130) |
| ↑ | Plasma | NASH patients | (91) | |
| ↑ | Liver | MCD-fed mice | (131) | |
| ↑ | Liver | Ldlr−/− mice fed an HFD | (132) | |
| ↑ | Liver | CXCL1 overexpression in HFD-fed mice | (16) | |
| NE | ↑ (NE to AAT ratio) | Circulation | NASH patients | (133) |
| ↑ | Liver | Western diet-fed mice | (134) | |
| LCN2 | ↑ | Circulation and hepatic non-parenchymal cell fraction | Apoe−/− mice fed an HFHCD | (135) |
| ↑ | Circulation and liver | NASH patients | (135) | |
| ↑ | Liver | NASH patients | (136) | |
| ↑ | Liver | Mice fed a high-fat, high-sugar diet | (137) | |
| ↑ | Liver | FLS mouse model | (138) | |
| NET formation | ↑ | Liver | STAM mice | (92) |
| ↑ (MPO-DNA levels) | Serum | NASH patients | (92) | |
| ↑ (citrullinated histone H3) | Liver | NASH patients | (139) | |
| ↑ | Liver | Mice fed an MCDHFD | (140) |
AAT, alpha-1-antitrypsin; APOE, apolipoprotein E; CXCL1, C-X-C motif chemokine ligand 1; FLS, fatty liver Shionogi; HFD, high-fat diet; HFHCD, high-fat, high-cholesterol diet; LCN2, lipocalin 2; LDLR, low-density lipoprotein receptor; MCD, methionine-choline-deficient diet; MCDHFD, methionine-choline-deficient high-fat diet; MPO, myeloperoxidase; NASH, nonalcoholic steatohepatitis; NE, neutrophil elastase; NET, neutrophil extracellular trap; STAM, Stelic animal model of NASH.