Figure 1.

The uptake of radioactive glucose in the whole brain, hippocampus, and cortex is reduced in aged degus. Radioactive glucose was injected via the tail vein, and 15 min later, glucose uptake was measured in (A) the whole brain, (B) hippocampus, and (C) cortex in 1- (control), 3-, 5-, and 6-year-old degus. The data represent the mean ± SEM of 4–5 independent biological replicates in three technical replicates. Statistical significance: ***p < 0.001 and ****p < 0.0001, by one-way ANOVA, followed by Bonferroni's post-hoc test.