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. 2021 Oct 11;15:733007. doi: 10.3389/fnint.2021.733007

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Copyright © 2021 Cisternas, Gherardelli, Salazar and Inestrosa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippocampal expression of Glut3, Glut4, and glycolytic enzymes is decreased in aged degus. Quantitative RT-PCR of (A) Glut1, (B) Glut3, (C) Glut4, (D) phosphofructokinase-1 (PFK-1), and (E) hexokinase-1 (HK) expression in hippocampal lysates from 1- (control), 3-, 5-, and 6-year-old degus. (F) Hippocampal slices obtained from 1- to 6-year-old degus were used to assess the activity of HK by ELISA. The data represent the mean ± SEM of five independent biological replicates in three technical replicates. Statistical significance: **p < 0.01, ***p < 0.001, and ****p < 0.0001 by one-way ANOVA, followed by Bonferroni's post-hoc test.