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Impairment of brain glucose metabolism in degus. Our data revealed an age-related progressive reduction in several glucose metabolic processes, such as hexokinase expression and activity, ATP levels, and glucose uptake and accumulation in the brains of 5- and 6-year-old degus. Overall, these alterations result in an energetic production deficit, which exacerbates neuroinflammation and neurodegeneration in aged degus.
