Table 3.
Strategies to improve the efficacy of vaccines and adoptive cell therapies by targeting TRM cells.
| Strategies | Examples | Ways to improve | References |
|---|---|---|---|
| Transcription Factors | Runx3, Bhlhe40, BATF, NAB1, NAB2 | Up-regulation | (40, 41, 78) |
| Cytokines | TGF-β、IL-10 | Increment | (33, 59) |
| Leukocyte surface antigen | CD39, CXCR6, PPAR-γ, SIRPG, KIR2DL4 | Activation | (41, 51, 81) |
| Cells | M1hot TAM cells, Reticular fibroblasts, Dendritic cells with high expression of IRF4 | Activation | (32, 55, 67) |
| Alveolar macrophage | Inhibition | (51) |