Table 4.
Molecules in mice or/and humans regulating lung TRM cells.
| The process lung TRM cells participate in | Species | Regulatory molecules | References |
|---|---|---|---|
| Anti-tumor immunity | Mouse | Runx3, NFATc1, CXCR6, TGF-β | (40, 41, 78) |
| Human | Eomes, CD39, CXCL9, paxillin, TGF-β, SIRPG, KIR2DL4 | (25, 32, 41, 74, 75, 79) | |
| Positive role in infection | Human | ICOSL, CD40, IL-6, IL-10 | (55, 59) |
| Negative role in infection | Mouse | TGF-β, IL-5, IL-13 | (15, 89) |
| Antivirus immunity | Mouse | CD69, CD38, CD103, CXCR3, IFN-γ, IRF4, PPAR-γ | (45, 50, 51, 67) |
| Human | IL-17A, CCL20, IL-23 | (42) | |
| Antibacterial Immunity | Mouse | IFN-γ,IL-12,IL-17,IL-18, CXCL5, CXCR3 | (46–49, 68, 70) |
| Association with asthma | Mouse | CD44, ST2, IFN-γ, perforin, granules | (18, 53, 54) |