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. 2021 Oct 11;12:712081. doi: 10.3389/fmicb.2021.712081

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Copyright © 2021 Li, Yang, Zhou, Disoma, Dong, Du, Zhang, Chen, Huang, Chen, Song, Chen, Liu, Li, Zheng, Liu, Razzaq, Chen, Tao, Yu, Feng, Liao, Peng, Jiang, Huang, Wu, Hu, Wang, Li and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differences in gut microbial diversity between COVID-19 and healthy controls (HC). (A) The rarefaction analysis between the number of samples and the number of species. As the number of samples increased, the number of species approached saturation in COVID-19 (n = 37) and HC (n = 10). (B) Compared with the HC, the number of species in COVID-19 was decreased significantly. *p < 0.05. (C,D) The principal component analysis (PCA) based on Bray–Curtis distance and the non-metric multidimensional scaling (NMDS) based on species level distribution showed that the gut taxonomic composition differed markedly between individuals in both COVID-19 patients and healthy controls (all p < 0.05; COVID-19).