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. 2021 Oct 11;12:712081. doi: 10.3389/fmicb.2021.712081

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Copyright © 2021 Li, Yang, Zhou, Disoma, Dong, Du, Zhang, Chen, Huang, Chen, Song, Chen, Liu, Li, Zheng, Liu, Razzaq, Chen, Tao, Yu, Feng, Liao, Peng, Jiang, Huang, Wu, Hu, Wang, Li and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Crucial KEGG orthology and pathways related to COVID-19. (A) A heat map shows 30 KO modules overrepresented between the COVID-19 patients and healthy controls, including 7 increasing modules and 23 decreasing modules in disease patients. (B) A bubble chart showing the top 15 enriched pathways with 9 significantly decreased KEGG pathways in COVID-19. (C) A bubble chart showing the top 15 enriched GO terms with 2 significantly increased GO term in COVID-19. (D) A network of significantly increased and decreased pathways of COVID-19 patients.