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. 2021 Oct 11;12:766170. doi: 10.3389/fimmu.2021.766170

Figure 2.

Figure 2

Bacterial administration exacerbates high fat diet-induced liver pathology. (A) Changes in body weight and liver/body weight ratios of mice in each group during the experimental period. Pi mice had a significantly lower body weight compared with RC mice at day 28 (n=6-10/group). (B) Hematoxylin and eosin staining of liver (scale bars, 100 μm). (C) Masson’s trichrome staining of the liver. (D) Hepatic contents of hydroxyproline (n=6-10/group). RC: C57BL/6N mice fed regular chow; Sham: Mice fed CDAHFD60 plus sham administration; Pi: Mice fed CDAHFD60 plus P. intermedia administration; Pg: Mice fed CDAHFD60 plus P. gingivalis administration, An: Mice fed CDAHFD60 plus A naeslundii administration, Vr: Mice fed CDAHFD60 plus V. rogosae administration. Data are expressed as the mean ± standard error of the mean (SEM). P values were calculated using one-way ANOVA with Tukey’s multiple comparisons test. *P < 0.05, **P < 0.005, ***P < 0.001, ****P < 0.0001.