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. 2021 Oct 11;12:733902. doi: 10.3389/fphar.2021.733902

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Copyright © 2021 Liu, Lin, Wu, Wang, Xie, Wu, Qin and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LincRNA00892 promoted the activation of CD4⁺ T cells and subsequent activation of B cells. (A) The CD69 levels expressed on the surface of both Jurkat and primary CD4⁺ T cells in negative control and lincRNA00892 overexpression groups were measured by flow cytometry. (B) The CD23 levels expressed on the surface of B cells cocultured with primary CD4⁺ T cells transfected with control vector or vector containing lincRNA00892 fragment were confirmed by flow cytometry. (C) The primary CD4⁺ T cells that transfected with control vector or vector that containing lincRNA00892 fragment were cocultured with B cells at a ratio of 1:1 or 4:1 for 3 days. The levels of IgG secreted by B cells were determined by ELISA. NC = negative control, OE = overexpression. **p < 0.01, *p < 0.05. The results are expressed as mean ± standard deviation. Student’s t-test was used for comparison of two groups.