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. 2021 Oct 18;14(10):dmm049157. doi: 10.1242/dmm.049157

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Macrocytic anaemia, splenomegaly, and increased erythropoiesis and megakaryopoiesis in Dp1Tyb mice. (A) Red blood cell (RBC) concentrations, haematocrit (HCT), haemoglobin, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and monocytes in the blood of WT or Dp1Tyb mice (cohort 1, females and males combined). (B) Flow cytometric analysis of splenocytes from female WT and Dp1Tyb mice (cohort 4), showing mean±s.e.m. numbers of splenocytes, transitional type (T)1, T2, T3, marginal zone (MZ), follicular (FO), plasmablasts (PB), plasma cells (PC), IgM and IgG1 memory B cells (MBC), and germinal centre (GC) B cells; mean±s.e.m. ratio of CD4⁺/CD8⁺ T cells; and mean±s.e.m. numbers of total or naive CD4⁺ or CD8⁺ T cells, CD62L⁺ or CD62L⁻ regulatory T cells (Treg), effector T cells, T follicular helper (Tfh) cells, CD8⁺ central memory (CM) and effector memory (EM) T cells, γδ T cells, natural killer (NK) cells, Ly6C^hi and Ly6C^lo monocytes (mono), dendritic cells (DC), neutrophils (Neut), macrophages, pro-erythroblasts (ProE), EryA, EryB and EryC erythroid progenitors, and immature (imm) and mature (mat) megakaryoblasts (MK). *0.01<q<0.05; **0.001<q<0.01; ****q<0.0001.