Table 2.
Association of diurnal cortisol pattern with baseline PWV (2007–2009) and 5-year progression of PWV controlling for demographic, behavioural and biomedical factors.
| Men | Women | |||||
|---|---|---|---|---|---|---|
| PWV at baseline | Differencea | (95%CI) | P-value | Differencea | (95%CI) | P-value |
| Slope in cortisol | ||||||
| Model 1b | 0.057 | (−0.013,0.127) | 0.11 | -0.013 | (−0.141,0.115) | 0.84 |
| Model 2c | 0.055 | (−0.013,0.123) | 0.11 | -0.030 | (−0.158,0.097) | 0.64 |
| Bedtime cortisol | ||||||
| Model 1b | 0.036 | (−0.036,0.107) | 0.33 | -0.031 | (−0.151,0.089) | 0.61 |
| Model 2c | 0.032 | (−0.037,0.101) | 0.36 | -0.056 | (−0.177,0.064) | 0.36 |
| Change in PWV (per 5 years) | Increasea | (95%CI) | P-value | Increasea | (95%CI) | P-value |
| Slope in cortisol | ||||||
| Model 1b | 0.043 | ( −0.055,0.141) | 0.39 | 0.173 | (0.013,0.333) | 0.03 |
| Model 2c | 0.034 | (−0.064,0.131) | 0.50 | 0.199 | (0.040,0.358) | 0.01 |
| Bedtime cortisol | ||||||
| Model 1b | 0.021 | (−0.079,0.120) | 0.69 | 0.181 | (0.034,0.328) | 0.02 |
| Model 2c | 0.012 | (−0.087,0.111) | 0.81 | 0.208 | (0.062,0.354) | 0.005 |
a
Differences or increases in PVW are per 1 SD higher value for each diurnal cortisol measure.
b
Adjusted for age, ethnic group, wake up time, mean arterial pressure at the time of PWV measurement.
c
Further adjusted for social class (low, middle, high), CES-D (quartiles), BMI, systolic blood pressure, hypertensive medication use, total cholesterol, diabetes, alcohol intake, smoking status.