Table 1.

Summary of the eight considered (sub)networks for each of two considered entire context-unspecific human PPI networks

Network name	Weighted	Unweighted	Dynamic	Static
Entire		$✓$		$✓$
Induced-Dynamic		$✓$	$✓$
Induced-Static		$✓$		$✓$
NetWalk-Dynamic		$✓$	$✓$
NetWalk-Static		$✓$		$✓$
NetWalk-Static*		$✓$		$✓$
wNetWalk-Dynamic	$✓$		$✓$
wNetWalk-Static*	$✓$			$✓$

One of the two entire context-unspecific networks is from HPRD [23], which is quite old, but we use it because many relevant aging-specific subnetworks were already inferred from it in the prior work (see text for details). The other entire context-unspecific network is from BioGRID [24], which we use as the most recent human PPI data (“Data” section). So, when we use HPRD, “Entire” represents the HPRD entire context-unspecific network, and the other seven aging-specific subnetworks are all inferred from HPRD. When we use BioGRID, “Entire” represents the BioGRID entire context-unspecific network, and the other seven aging-specific subnetworks are all inferred from BioGRID. We study HPRD (and its associated aging-specific subnetworks) separately from BioGRID (and its associated aging-specific subnetworks), with the goal of evaluating whether results that we observe for HPRD also hold for the most recent BioGRID data