Central Illustration.

Diagnoses of Wild-Type Transthyretin Amyloidosis Versus Variant Transthyretin Amyloidosis With Cardiac Mutations

Diagnoses in THAOS (the Transthyretin Amyloidosis Outcomes Survey) are shown by year. Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) diagnoses increased from 2 in 2005 to >100 per year starting in 2016. Diagnoses of variant transthyretin amyloidosis (ATTRv amyloidosis) with cardiac mutations increased from 3 in 2005 to 37 in 2011, after which they plateaued. ∗Year of diagnosis missing for 87 patients with ATTRwt amyloidosis and 116 patients with ATTRv amyloidosis with cardiac mutations.