Table 2.
Clinical Characteristics in Patients With ATTRwt Amyloidosis by Region
| Overall (N = 1,027) | United States (n = 646) | Rest of the World (n = 381) | |
|---|---|---|---|
| Age at onset (y) | |||
| n | 1,027 | 646 | 381 |
| Mean ± SD | 68.7 ± 11.1 | 68.0 ± 11.2 | 69.8 ± 10.8 |
| Median (Q1, Q3) | 69.8 (62.4, 76.6) | 69.1 (62.0, 76.0) | 70.9 (63.1, 77.5) |
| Age at diagnosis (y) | |||
| n | 947 | 604 | 343 |
| Mean ± SD | 76.1 ± 7.1 | 75.8 ± 7.1 | 76.7 ± 7.2 |
| Median (Q1, Q3) | 76.4 (71.5, 81.0) | 76.1 (71.2, 80.4) | 77.4 (72.2, 81.7) |
| Time to diagnosis from symptom onseta (mo) | |||
| n | 947 | 604 | 343 |
| Mean ± SD | 90.4 ± 104.2 | 93.6 ± 112.0 | 84.8 ± 88.6 |
| Median (Q1, Q3) | 56.5 (12.0, 131.6) | 53.1 (11.8, 138.3) | 61.0 (13.6, 121.0) |
| Diagnostic modality, n (%) | |||
| Tissue biopsyb | 594 (57.8) | 388 (60.1) | 206 (54.1) |
| Cardiac tissue | 215 (20.9) | 142 (22.0) | 73 (19.2) |
| Noncardiac tissue | 45 (4.4) | 35 (5.4) | 10 (2.6) |
| Cardiac + noncardiac tissue | 28 (2.7) | 25 (3.9) | 3 (0.8) |
| Bone scintigraphy | 429 (41.8) | 257 (39.8) | 172 (45.1) |
| Missing/Unknown | 4 (0.4) | 1 (0.2) | 3 (0.8) |
Including all patients in THAOS (the Transthyretin Amyloidosis Outcomes Survey) with ATTRwt amyloidosis and any symptom at enrollment defined as ATTR amyloidosis–related by the investigator; 42 patients did not have ATTR amyloidosis–related symptoms at enrollment.
ATTR amyloidosis = transthyretin amyloidosis; other abbreviations as in Table 1.
a
Any symptom (cardiac or noncardiac) defined as ATTR amyloidosis–related by the investigator.
b
Tissue biopsy type not available for 306 patients.