Figure 1:

Effect of prenatal exposure to the phthalate mixture on estrous cyclicity at 11 and 13 months of age in the F1 generation of female mice. Percentage of days in proestrus, estrus, and metestrus/diestrus were calculated and compared to controls in each treatment group at 11 months (panel A: control = 10 females/treatment group, 20 µg/kg/day = 9 females/treatment group, 200 µg/kg/day = 8–9 females/treatment group, 200 mg/kg/day = 9 females/treatment group) and 13 months (panel B: control = 10 females/treatment group, 20 µg/kg/day = 9 females/treatment group, 200 µg/kg/day = 9 females/treatment group, 200 mg/kg/day = 8 females/treatment group). Graphs represent mean percentages ± SEM. Asterisks (*) indicate significant differences compared to the control (P < 0.05) and carets (^{^}) indicate borderline significance compared to the control (0.05 < P < 0.1)