Figure 4:

Effects of prenatal exposure to the phthalate mixture on time to mating and fertility indices at 13 months of age in the F1 generation of female mice. Breeding was monitored by examining time to pregnancy (panel A: control = 8 females/treatment group, 20 µg/kg/day = 8 females/treatment group, 200 µg/kg/day = 8 females/treatment group, 200 mg/kg/day = 5 females/treatment group), mating index (panel B: control = 10 females/treatment group, 20 µg/kg/day = 9 females/treatment group, 200 µg/kg/day = 9 females/treatment group, 200 mg/kg/day = 8 females/treatment group), pregnancy rate (panel C: control = 10 females/treatment group, 20 µg/kg/day = 9 females/treatment group, 200 µg/kg/day = 9 females/treatment group, 200 mg/kg/day = 8 females/treatment group), fertility index (panel D: control = 10 females/treatment group, 20 µg/kg/day = 9 females/treatment group, 200 µg/kg/day = 9 females/treatment group, 200 mg/kg/day = 8 females/treatment group), gestational index (panel E: control = 7 females/treatment group, 20 µg/kg/day = 8 females/treatment group, 200 µg/kg/day = 5 females/treatment group, 200 mg/kg/day = 7 females/treatment group), and females who gave birth (panel F: control = 10 females/treatment group, 20 µg/kg/day = 9 females/treatment group, 200 µg/kg/day = 9 females/treatment group, 200 mg/kg/day = 8 females/treatment group). Graphs represent mean percentages (± SEM for time to pregnancy) in the F1 generation at 13 months. Asterisks (*) indicate significant differences compared to the control (P < 0.05) and carets (^{^}) indicate borderline significance compared to the control (0.05 < P < 0.1)