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. 2021 Oct 11;22(6):1420. doi: 10.3892/etm.2021.10855

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Copyright: © Sandech et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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A proposed potential inhibitory mechanism for improvement of the endothelial injury and inflammatory reaction of brain blood vessels in STZ induced-diabetic rats by gymnemic acid. The inner wall of blood vessels impacts high blood glucose conditions, resulting in brain hypoxia-induced angiogenesis and neovascular remodeling by upregulating Ang-1 and VEGF expression. VEGF protein and receptors increase lumen formation and decrease lumen diameter by proliferation of myointimal cells and collagen deposition, and Ang-1 serves important roles in angiogenesis and vascular development. STZ, streptozotocin; VEGF, vascular endothelial growth factor.