Table 1.
Patient characteristics
| Patient characteristic | Total (n = 84) | Cohort A (n = 53) | Cohort B (n = 31) | p value |
|---|---|---|---|---|
| Age, years | ||||
| Mean (SD) | 44.5 (11.9) | 41.4 (9.9) | 49.8 (13.2) | 0.001 |
| Range | 22–75 | 22–62 | 27–75 | |
| Body mass index, kg/m2 | ||||
| Mean (SD) | 22.1 (2.8) | 22.0 (3.0) | 22.2 (2.5) | 0.403 |
| Range | 17.8–32.5 | 17.8–32.5 | 17.9–27.5 | |
| Smokers, n (%) | 18 (21.4) | 9 (17.0) | 9 (29.0) | 0.430 |
| Comorbidities, n (%) | ||||
| Hypothyroidism | 9 (10.7) | 3 (5.7) | 6 (19.4) | 0.050 |
| Hypertension | 10 (11.9) | 3 (5.7) | 7 (22.6) | 0.021 |
| Depression | 3 (3.6) | 0 (0.0) | 3 (9.7) | 0.021 |
| Prior therapy, n (%) | ||||
| Radiation therapy | 7 (8.3) | 0 (0.0) | 7 (22.6) | 0.000 |
| Neoadjuvant chemotherapy | 21 (25.0) | 14 (26.4) | 7 (22.6) | 0.695 |
| Endocrine therapy | 23 (27.4) | 8 (15.1) | 15 (48.4) | 0.001 |
| Indication, n (%) | ||||
| Prophylactica | 37 (44.0) | 29 (54.7) | 8 (25.8) | 0.021 |
| Invasive breast cancer | 48 (57.1) | 34 (64.2) | 14 (45.2) | 0.090 |
| Precancerosis/DCIS | 16 (19.0) | 10 (18.9) | 6 (19.4) | 0.956 |
a
Including confirmed BRCA mutations and breast cancer in the family history.