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. Author manuscript; available in PMC: 2022 Mar 21.
Published in final edited form as: Nat Microbiol. 2021 Sep 21;6(10):1233–1244. doi: 10.1038/s41564-021-00972-2

Extended Data Fig. 4. Identification of putative public clonotype members genetically similar to AZD8895 in the antibody variable gene repertoires of virus-naïve individuals.

Extended Data Fig. 4.

Antibody variable gene sequences collected from healthy individuals (HIP1, 2, or 3) prior to the pandemic with the same sequence features as AZD8895 heavy chain and light chain are aligned.

a. WebLogo plots of heavy chain (top) and light chain (bottom) sequences from three different adult donors and cord blood samples with the features of the public clonotype. The sequence features and contact residues used in AZD8895 are highlighted in red boxes below each multiple sequence alignment.

b. Since the light chain plots in (a) showed restricted diversity, here we show amino acid alignments for the top five representative light chains that occurred most frequently in the three adult donors studied (HIP1, 2, or 3).