Skip to main content
. Author manuscript; available in PMC: 2022 Mar 21.
Published in final edited form as: Nat Microbiol. 2021 Sep 21;6(10):1233–1244. doi: 10.1038/s41564-021-00972-2

Extended Data Fig. 5. Details of AZD1061 interaction with SARS-CoV-2 S protein RBD.

Extended Data Fig. 5.

a. Detailed AZD1061 HCDR3 loop structure. Short-range hydrogen bonds, stabilizing the loop conformation, are shown as dashed magenta lines.

b.Residues of AZD1061 light chain form aromatic stacking interactions and hydrogen bonds with HCDR3 to further stabilize the HCDR3 loop. LCDR1 residue Y38 is colored in magenta to match the LCDR1 coloring in panels (c) and (d).

c. Long LCDR1, HCDR2, and HCDR3 form complementary binding surface to the RBD epitope. RBD is shown as surface representation in grey. AZD1061 heavy chain is colored in yellow with HCDR3 in orange, and the light chain in pink with LCDR1 in magenta.

d. 180° rotation view of panel c.

e. Comparison of AZD1061 binding with the previously published mAbs C119 and C135.