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. 2021 Oct 22;8(1):e000559. doi: 10.1136/lupus-2021-000559

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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KYN/TRP pathway metabolite ratios in subjects with SLE compared with healthy controls (HC). Serum metabolite ratios measured by HPLC-MS in 74 subjects with SLE and 74 HC. Subjects with SLE demonstrate a significantly higher KYN/TRP ratio (A) and QA/KA ratio (B) than HC. HPLC-MS, high-performance liquid chromatography-mass spectrometry; KA, kynurenic acid; KYN, kynurenine; QA, quinolinic acid; TRP, tryptophan.