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. 2021 Oct 22;11(10):e048443. doi: 10.1136/bmjopen-2020-048443

Table 2.

Analysis of interaction between groups

Attribute (reference level) Level Model 4 Model 5
Children Children and caregivers
OR 95% CI P value OR 95% CI P value
Duration of treatment and visit frequency (3 months of treatment, 1 clinic visit) 6 months 1 visit 1.077 0.866 to 1.339 0.505 0.982 0.845 to 1.141 0.810
3 months 3 visits 1.154 0.893 to 1.491 0.273 1.120 0.939 to 1.336 0.208
6 months 6 visits 0.975 0.780 to 1.220 0.828 0.899 0.771 to 1.049 0.178
Dosing frequency (daily) Bi-weekly 1.128 0.903 to 1.410 0.288 1.171* 1.005 to 1.364 0.043
Weekly 1.014 0.785 to 1.310 0.914 1.197* 1.003 to 1.427 0.046
Monthly 0.912 0.737 to 1.129 0.399 1.175* 1.013 to 1.363 0.033
Pill size and formulation (2 small pills) 6 small 0.828 0.665 to 1.030 0.090 0.826* 0.710 to 0.961 0.013
2 large 0.886 0.689 to 1.138 0.343 0.812* 0.682 to 0.967 0.019
Dissolvable 1.022 0.821 to 1.272 0.847 1.001 0.859 to 1.165 0.994
Taste (bitter) Not bitter 2.195† 1.932 to 2.495 <0.001 1.960† 1.794 to 2.140 <0.001
Waiting time (45 min) 15 min 1.294* 1.039 to 1.613 0.022 1.183* 1.015 to 1.378 0.032
90 min 1.073 0.832 to 1.385 0.587 1.003 0.841 to 1.196 0.973
3 hours 0.800* 0.642 to 0.995 0.045 0.758† 0.651 to 0.883 <0.001
Operating hours (regular clinic hours) Including early mornings 1.007 0.796 to 1.274 0.953 1.011 0.862 to 1.187 0.889
Including evenings 0.961 0.748 to 1.236 0.759 0.946 0.795 to 1.126 0.535
Including weekends 0.966 0.786 to 1.188 0.745 0.981 0.848 to 1.135 0.796
Cost (US$0.75) Free 1.451† 1.164 to 1.808 0.001 1.243† 1.070 to 1.444 0.004
US$3.00 0.824 0.641 to 1.059 0.130 0.781† 0.656 to 0.930 0.006
US$6.00 0.535† 0.429 to 0.666 <0.001 0.523† 0.448 to 0.610 <0.001
Caregivers Healthcare providers
Duration of treatment and visit frequency (3 months of treatment, 1 clinic visit) 6 months 1 visit 0.836 0.618 to 1.132 0.247 0.825 0.622 to 1.094 0.181
3 months 3 visits 0.942 0.660 to 1.344 0.741 0.794 0.565 to 1.115 0.183
6 months 6 visits 0.846 0.619 to 1.155 0.293 0.862 0.640 to 1.160 0.328
Dosing frequency (daily) Bi-weekly 1.090 0.801 to 1.483 0.585 1.919† 1.432 to 2.571 <0.001
Weekly 1.394 0.977 to 1.989 0.067 2.138† 1.528 to 2.991 <0.001
Monthly 1.645† 1.219 to 2.219 0.001 3.026* 2.249 to 4.071 <0.001
Pill size and formulation (2 small pills) 6 small 0.996 0.734 to 1.351 0.980 0.739* 0.550 to 0.993 0.045
2 large 0.847 0.596 to 1.204 0.355 0.824 0.591 to 1.150 0.255
Dissolvable 0.964 0.709 to 1.310 0.814 0.885 0.660 to 1.185 0.411
Taste (bitter) Not bitter 0.809* 0.677 to 0.967 0.020 1.337† 1.128 to 1.585 0.001
Waiting time (45 min) 15 min 0.844 0.621 to 1.149 0.281 0.966 0.715 to 1.306 0.824
90 min 0.884 0.620 to 1.259 0.494 0.782 0.560 to 1.093 0.150
3 hours 0.903 0.664 to 1.227 0.513 0.828 0.612 to 1.120 0.220
Operating hours (regular clinic hours) Including early mornings 1.012 0.732 to 1.398 0.944 1.217 0.900 to 1.647 0.202
Including evenings 0.969 0.682 to 1.376 0.859 1.364 0.979 to 1.901 0.066
Including weekends 1.028 0.767 to 1.378 0.851 1.320* 1.003 to 1.736 0.047
Cost (US$0.75) Free 0.751 0.554 to 1.017 0.064 1.024 0.773 to 1.357 0.867
US$3.00 0.903 0.636 to 1.283 0.569 0.892 0.637 to 1.248 0.504
US$6.00 0.957 0.703 to 1.303 0.781 0.788 0.581 to 1.070 0.127

*Significant at 95%.

†Significant at 99%.