Table 2.
Baseline differences between APOEε4+ and APOEε4–.
|
CBF (ml/100 g/min) |
CVRi (mmHg/(ml/100 g/min)) |
|||||
|---|---|---|---|---|---|---|
| APOEε4– | APOEε4+ | β-APOE; p-value | APOEε4– | APOEε4+ | β-APOE; p-value | |
| ACA proximal | 35.0 ± 7.5 | 38.5 ± 10.0 | 3.88; 0.01a | 2.7 ± 0.7 | 2.5 ± 0.9 | R –0.27; 0.02 |
| ACA middle | 41.1 ± 8.1 | 44.0 ± 9.3 | 3.31; 0.02a | 2.3 ± 0.6 | 2.1 ± 0.6 | R –0.14; 0.11 |
| ACA distal | 40.3 ± 8.6 | 41.8 ± 8.4 | R 1.59; 0.28 | 2.3 ± 0.7 | 2.2 ± 0.6 | R –0.07; 0.42 |
| MCA proximal | 37.2 ± 7.1 | 41.2 ± 9.4 | 4.36; <0.01a | 2.5 ± 0.5 | 2.3 ± 0.6 | R –0.23; 0.02 |
| MCA middle | 38.1 ± 8.5 | 41.4 ± 10.0 | 3.82; 0.01a | 2.5 ± 0.6 | 2.3 ± 0.6 | R –0.19; 0.07 |
| MCA distal | 37.9 ± 8.4 | 39.6 ± 9.3 | 2.13; 0.13 | 2.5 ± 0.7 | 2.4 ± 0.7 | R –0.07; 0.51 |
| PCA proximal | 52.2 ± 9.2 | 55.3 ± 8.1 | 2.96; 0.04 | 1.8 ± 0.4 | 1.6 ± 0.3 | R –0.10; 0.07 |
| PCA middle | 55.2 ± 9.9 | 57.1 ± 8.9 | 1.99; 0.21 | 1.7 ± 0.4 | 1.6 ± 0.3 | R –0.07; 0.26 |
| PCA distal | 47.8 ± 9.1 | 49.1 ± 8.3 | R 0.99; 0.52 | 1.9 ± 0.5 | 1.9 ± 0.4 | R –0.04; 0.56 |
The shown values are mean ± standard deviation along with the coefficient estimate for APOE and p-values emerging from the applied linear regression models. Betas are the coefficient estimates from the conducted regression analyses.
R indicates that robust regression was used.
aIndicates findings that survived false discovery rate correction (p < 0.05).
ACA: anterior cerebral artery; APOEε4: apolipoprotein ε4; CBF: cerebral blood flow; CVRi: cerebrovascular resistance index; MCA: middle cerebral artery; PCA: posterior cerebral artery.