Table 4.
Significant interactions between APOEε4 carriership and (a) hemodynamic measures in predicting baseline cognitive scores; (b) baseline hemodynamics in predicting changes in cognitive scores; (c) hemodynamic changes in predicting changes in cognitive scores.
|
Baseline cognition–baseline hemodynamics |
Cognitive change–baseline hemodynamics |
Cognitive change–hemodynamic change |
||||
|---|---|---|---|---|---|---|
| Cognitive metric | Measure/territory | β-APOE; p-value | Measure/territory | β-APOE; p-value | Measure/territory | β-APOE; p-value |
| Immediate recall | – | – | CBF proximal ACA | 0.07; 0.03 | CBF distal MCA | R –0.59; 0.04 |
| CVRi proximal ACA | 0.56; 0.04 | |||||
| CVRi distal ACA | 0.54; 0.04 | |||||
| CVRi distal MCA | R 0.71; 0.01 | |||||
| Delayed recall | – | – | – | – | CBF proximal ACA | R –1.2; <0.01 |
| CBF proximal MCA | R –0.91; 0.03 | |||||
| CBF middle ACA | R –0.84; 0.04 | |||||
| CBF middle MCA | R –0.90; 0.03 | |||||
| CVRi proximal ACA | R 0.95; 0.02 | |||||
| Verbal fluency | CVRi proximal ACA | –1.67; 0.04 | CVRi proximal PCA | 3.95; 0.05 | CBF proximal ACA | R 1.32; 0.05 |
| CBF proximal PCA | 1.88; <0.01 | |||||
| CBF distal ACA | R 1.46; 0.03 | |||||
| CBF distal MCA | R 1.36; 0.05 | |||||
| CVRi proximal PCA | R –1.98; 0.01 | |||||
| CVRi middle PCA | R –1.49; 0.03 | |||||
| CVRi distal ACA | –1.53; 0.02 | |||||
| Spatial memory | – | – | CVRi proximal PCA | R 5.8; 0.02 | – | – |
| CVRi middle PCA | R 4.9; 0.04 | |||||
Betas represent the coefficient estimates from the conducted regression analyses.
R indicates that robust linear regression was used; bold indicates values that survived an FDR at a level of 0.05.
ACA: anterior cerebral artery; CBF: cerebral blood flow; CVRi: cerebrovascular resistance index; MCA: middle cerebral artery; PCA: posterior cerebral artery.